Structural pharmacogenomics of drug-associated SNPs in oral squamous cell carcinoma.

ABSTRACT:

Introduction

Pharmacogenomics enables the interpretation of how genetic variation influences drug response, offering a route toward precision oncology. Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy characterized by marked inter-individual variability in response to chemotherapy and radiotherapy, particularly in South Asian populations. However, the mechanism through which OSCC-associated genetic variants alter protein structure and drug interactions remains poorly understood.

Methods

To address this, we integrated OSCC-specific variants from a Southern Indian patient cohort with pharmacogenomic annotations from ClinPGx. First, OSCC variants were mapped to drug-associated single-nucleotide proteins, yielding 22 protein-altering variants. Second, struct

SUBMITTER: Sunil P 

PROVIDER: S-EPMC12935321 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature