Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews.

ABSTRACT:

Background

Digestive system cancers (DSCs) constitute a significant number of cancer cases and are closely associated with modifiable risk factors.

Objective

This umbrella review synthesizes evidence from meta-analyses on the association between dietary polyphenol consumption and the risk of DSCs, addressing limitations in the literature and identifying optimal polyphenol types and doses.

Methods

Following Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across PubMed, Scopus and Web of Science until April 2025, using specific keywords related to polyphenols and DSCs. Eligible studies included meta-analyses that examined polyphenol intake and DSC risk. The quality was assessed via the AMSTA

SUBMITTER: Amjadi A 

PROVIDER: S-EPMC12935476 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature