Synbiotic Combination of <i>Lactococcus lactis</i> LB1022 and Fructo-Oligosaccharides Mitigates the Atopic March by Modulating the Microbiota-Gut-Skin-Lung Axis.

ABSTRACT: Dysregulated gut microbiota is increasingly recognized as a major contributor to allergic diseases and their progression. A key clinical manifestation of this progression is the atopic march, in which atopic dermatitis (AD) precedes the development of allergic airway disease. Although prebiotics and probiotics individually improve AD symptoms, their combined use as synbiotics, especially with regard to preventing the progression from cutaneous inflammation to airway hypersensitivity, has not been clearly established. In this study, we assessed the biological activity of a synbiotic composed of fructo-oligosaccharides (FOS) and Lactococcus lactis LB1022 in an ovalbumin (OVA)-induced murine model of AD and asthma-like inflammation. Female BALB/c mice were treated for eight weeks with

SUBMITTER: Baek J 

PROVIDER: S-EPMC12935502 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature