Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

ABSTRACT: Body-brain communication has emerged as a key regulator of tissue homeostasis^1-5. Solid tumours are innervated by different branches of the peripheral nervous system and increased tumour innervation is associated with poor cancer outcomes^6-8. However, it remains unclear how the brain senses and responds to tumours in peripheral organs, and how tumour-brain communication influences cancer immunity. Here we identify a tumour-brain axis that promotes oncogenesis by establishing an immune-suppressive tumour microenvironment. Combining genetically engineered mouse models with neural tracing, tissue imaging and single-cell transcriptomics, we demonstrate that lung adenocarcinoma induces innervation and functional engagement of vagal sensory neurons, a major interoceptive sy

SUBMITTER: Wei HK 

PROVIDER: S-EPMC12935554 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature