Translational relevance of animal models available on brain arteriovenous malformations, a systematic review.

ABSTRACT: We conducted a systematic review to identify and evaluate animal models of true brain arteriovenous malformations (bAVMs), focusing on how they replicate human disease. Outcomes assessed included bAVM growth, rupture, seizures, and survival. The review adhered to PRISMA guidelines and SYRCLE's protocol for animal studies. A search on PubMed and Embase was conducted (April 19, 2023; updated October 24, 2024). Exclusion criteria were; (1) Not an original, peer-reviewed full length research article, (2) not an in vivo study, (3) no bAVM induction, (4) no appropriate control group, (5) no histological or anatomical assessment during the bAVM follow-up, (6) outcome of the bAVM not reported. Meta analyses were planned for all key parameters. Risk of bias and image duplication assessments were co

SUBMITTER: Keranen S 

PROVIDER: S-EPMC12935589 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature