Associations of sphingosine-1-phosphate with soluble P-selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment.

ABSTRACT: Patients with overt cerebral ischemia are at risk for adverse events after hospital discharge. Sphingosine-1-phosphate is a potent lipid mediator produced and secreted by platelets, which is inhibited via acetylsalicylic acid (ASA). The associations of sphingosine-1-phosphate with biomarkers of platelet activation, i.e., thromboxane B₂ and soluble P-selectin, as well as with clinical outcome in ischemic stroke or transient ischemic attack patients' subgroups with and without ASA has not yet been investigated. The bioMARKers in STROKE (MARK-STROKE) cohort is a prospective, single-center, observational study including adult patients with a diagnosis of ischemic stroke or transient ischemic attack. Sphingosine-1-phosphate, thromboxane B₂, and soluble P-selectin were meas

SUBMITTER: Gloyer NO 

PROVIDER: S-EPMC12935708 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature