Attenuating amiodarone-induced lung toxicity by the vitamin D receptor activator paricalcitol in rats: targeting TLR4/NF-κB/HIF-1α and TGF-β/Smad signaling pathways.

ABSTRACT: Amiodarone, an antiarrhythmic drug, has been reported to precipitate lung injury by various mechanisms. Vitamin D receptor (VDR) is extensively expressed in the lung, and the disrupted vitamin D/VDR axis may underlie various lung disorders. Therefore, the current study intended to explore the beneficial impact of paricalcitol, a VDR activator, on amiodarone-provoked lung injury and elucidate its possible involved molecular mechanisms. Male Wistar rats were intraperitoneally injected with paricalcitol (0.2 µg/kg) and orally administered amiodarone (40 mg/kg) once daily for four weeks. Our findings revealed that paricalcitol diminished BALF leucocyte count and total protein, serum LDH activity, and pulmonary histopathological changes and counteracted pulmonary oxidative stress. Moreover, par

SUBMITTER: El-Waseif AG 

PROVIDER: S-EPMC12935821 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature