Brain-type natriuretic peptide is a useful biomarker of cardiovascular disease and predictor of cardiac-related mortality in chimpanzees (Pan troglodytes).

ABSTRACT:

Objective

To validate the use of brain-type natriuretic peptide (BNP) for detecting and monitoring cardiac dysfunction in captive chimpanzees (Pan troglodytes).

Methods

We analyzed cross-sectional (N = 175) and longitudinal (N = 76) BNP, echocardiogram, ECG, and pathology data from living and deceased captive chimpanzees to examine age and sex effects and to assess the usefulness of BNP for detecting cardiovascular disease and predicting mortality. The study period was from July 2010 through October 2024.

Results

Brain-type natriuretic peptide values were significantly associated with age, and males exhibited significantly higher BNP values than females. Brain-type natriuretic peptide values were significantly heritable, with over half of variation in BNP being attrib

SUBMITTER: Achorn AM 

PROVIDER: S-EPMC12936050 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature