Synergistic Chemopreventive Effects of Curcumin, Gingerol, and Shogaol on HeLa Cervical Cancer Cells.

ABSTRACT:

Objective

Bioactive compounds including curcumin, gingerols, and shogaols possess strong anti-inflammatory and anti-tumour properties. However, their combined efficacy has yet to be fully explored. This study aimed to investigate the chemopreventive potential of individual and combined treatments of 6-/10-gingerols (6-/10-G), 6-/10-shogaols (6-/10-S), and curcumin (Cur) in HeLa cervical cancer cells.

Methods

HeLa cell viability was evaluated using the MTT assay following a 24-hour treatment with a wide range of concentrations and ratios of the bioactive compounds. The combination index was analysed using the Chou-Talalay method, and apoptotic cells were assessed via flow cytometry with Annexin V/FITC-PI staining.

Results

We found that the optimal formulation of Cur in

SUBMITTER: Abdull Rahim U 

PROVIDER: S-EPMC12936120 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature