A new oxidative stress-related lncRNA signature predicts the prognosis of colorectal cancer patients.

ABSTRACT: Colorectal cancer (CRC) is a common malignant tumor of the digestive system with a high incidence. Increasing evidence suggests that oxidative stress (OS) generates high levels of reactive oxygen species (ROS) and free radicals and is a significant factor in aging and disease. However, the predictive value of OS-related long non-coding RNA (lncRNA) in CRC is unclear. We constructed a survival predictor based on OS-related lncRNAs obtained from the Cancer Genome Atlas (TCGA-COAD) to predict the prognosis of patients with CRC. The feature includes four lncRNAs, LINC02474, AL513550.1, SNHG16, and AL161729.4. The OS-related lncRNA signature demonstrated superior predictive accuracy to conventional clinicopathological parameters, with an area under the receiver operating characteristic curve (A

SUBMITTER: Chen P 

PROVIDER: S-EPMC12936229 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature