Differential Associations of Lipid Profiles with Dementia and Cardiovascular Disease: Findings from the UK Biobank Cohort.

ABSTRACT:

Purpose

Lowering low-density lipoprotein cholesterol (LDL-C) is crucial for cardiovascular disease (CVD) prevention, but its impact on cognitive function-and the potential differences by dementia subtype and cholesterol-lowering medication use-remain unclear. This study aimed to examine the associations between lipid levels and dementia and CVD risks, considering dementia subtypes and cholesterol-lowering medication use.

Materials and methods

A prospective cohort study was conducted using UK Biobank data. Serum lipid levels, including LDL-C, high-density lipoprotein cholesterol (HDL-C), triglycerides, total cholesterol, and remnant cholesterol, were categorized into clinically relevant ranges. Accounting for cholesterol-lowering medication use, the primary outcomes were inci

SUBMITTER: Lee JH 

PROVIDER: S-EPMC12936509 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature