Correlation between umbilical cord concentration of the growth hormone-IGF axis and small for gestational age: A single-center retrospective, observational study.

ABSTRACT:

Objective

To ascertain the association between small for gestational age (SGA) and growth hormone (GH)-insulin-like growth factor (IGF) system status.

Methods

This retrospective, observational single-center study at a tertiary hospital classified 175 newborns into two groups based on their gestational age and birth weight: SGA (n = 87) or appropriate for gestational age (AGA; n = 88). Umbilical cord blood samples were collected during delivery, and GH, IGF-1, and IGF-binding protein-3 (IGFBP-3) levels were measured using electrochemiluminescence immunoassay, liquid chromatography-tandem mass spectrometry, and chemiluminescence immunoassay, respectively.

Results

Compared with the AGA group, the GH concentration was significantly higher in the SGA group and the IGF-1 co

SUBMITTER: Wen J 

PROVIDER: S-EPMC12936639 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature