The association of umbilical cord blood neurofilament light with non-reassuring fetal status: A prospective observational study.

ABSTRACT:

Objective

Early detection of hypoxic-ischemic encephalopathy (HIE) in neonates is critical. We conducted a pilot cohort study to determine the feasibility of collecting umbilical cord blood samples for neurofilament light (NfL) and to assess the association of NfL with non-reassuring fetal status and other cord biomarkers. We aimed to address (1) Feasibility of cord NfL sample collection and analysis; (2) Association of NfL with non-reassuring fetal status (CTG changes and/or documented non-reassuring fetal status), neonatal intensive care unit (NICU) admission and length of stay; (3) Correlation of NfL with other cord biomarkers.

Methods

This was a prospective cohort study performed in a single, large tertiary and quaternary referral hospital. A total of 108 maternal partic

SUBMITTER: Zalcberg D 

PROVIDER: S-EPMC12936647 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature