Heat shock suppresses the innate immune response of bovine endometrial epithelial cells.

ABSTRACT:

Abstract

With rising global temperatures, it is imperative to determine the impact of heat stress on the physiology of food-producing animals. Dairy cows are susceptible to uterine diseases that reduce fertility. Immune function is important in the development and progression of disease; however, the effect of heat shock on the innate immune capacity of endometrial epithelial cells remains underexplored. Here, we investigated how heat shock alters the innate immune response and mitochondrial respiration of bovine endometrial epithelial cells. Primary endometrial epithelial cells were collected from postpartum cows and cultured in the presence of lipopolysaccharide under thermoneutral (38.5°C) or heat shock (40.0°C) conditions. Time-course and sequential heat shock experiments were

SUBMITTER: Tariq A 

PROVIDER: S-EPMC12936813 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature