Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome.

ABSTRACT:

Objective

Cytokine storm syndrome (CSS), commonly associated with hemophagocytic lymphohistiocytosis (HLH), is a fatal hyperinflammatory syndrome. Differentiating the underlying diseases responsible for CSS is essential for timely therapeutic decisions. This study explored the clinical usefulness of serum cytokine profiling in distinguishing underlying diseases in patients with CSS.

Methods

Serum samples were collected from 143 adult and pediatric patients with CSS and 22 healthy controls. The cohort included patients with various diagnoses of primary and secondary HLH and Kawasaki disease (KD)-like hyperinflammatory syndromes. Serum levels of 48 cytokines were analyzed in 97 patients using a bead-based multiplex immunoassay (Luminex assay). Serum levels of interferon alpha

SUBMITTER: Kaneko S 

PROVIDER: S-EPMC12936889 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature