Performance of an Idiopathic Pulmonary Fibrosis-Derived Multibiomarker Panel for Rheumatoid Arthritis-Associated Interstitial Lung Disease.

ABSTRACT:

Objective

To assess whether a panel of peripheral blood biomarkers associated with idiopathic pulmonary fibrosis (IPF) is also associated with interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) using three independent cohorts.

Methods

We first assessed the association of a panel of IPF-associated biomarkers with prevalent ILD among two separate RA cohorts (n = 93 and n = 71). Concentrations of eight IPF-related biomarkers (eotaxin, Flt-3L, interleukin-8, macrophage-derived chemokine, monocyte chemoattractant protein 1, and matrix metalloproteinase 2/7/9 [MMP-2/7/9]) were measured, standardized, and summed to generate a multibiomarker score. We subsequently validated the association of this score (minus MMP-2) with prevalent and incident ILD in an inde

SUBMITTER: Luedders BA 

PROVIDER: S-EPMC12936895 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature