Curation and validation of electronic medical record-based dementia diagnoses in the VA Million Veteran Program.

ABSTRACT:

Background

The age distribution and diversity of the VA Million Veteran Program (MVP) cohort make it a valuable resource for studying the genetics of Alzheimer's disease (AD) and related dementias (ADRD).

Objective

We present and evaluate the performance of several International Classification of Diseases (ICD) code-based classification algorithms for AD, ADRD, and dementia for use in MVP genetic studies and other studies using VA electronic medical record (EMR) data. These were benchmarked relative to existing ICD algorithms and AD-medication-identified cases.

Methods

We used chart review of n = 103 MVP participants to evaluate diagnostic utility of the algorithms. Suitability for genetic studies was examined by assessing association with APOE ε4, the stronges

SUBMITTER: Merritt VC 

PROVIDER: S-EPMC12937003 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature