Varying Influence of Menstrual Cycle Phase and Hormonal Contraceptive Use on Resistance Exercise-Induced Circulating Extracellular Vesicle and Metabolite Signalling.

ABSTRACT: Resistance exercise augments circulating extracellular vesicle (EV) and metabolite signalling in manners that assist musculoskeletal and systemic adaptations. Women are often underrepresented in exercise research and recent attention has focused on whether hormonal fluctuations during the menstrual cycle and use of hormonal contraception (HC) impact exercise performance and adaptation. We investigated if menstrual phase (follicular and luteal) or HC usage (oral contraceptive pill and hormonal intrauterine device) impact the EV and metabolite response to exercise. Overall, we observed an exercise-induced response across all four groups for EV microRNAs and circulating metabolites. Women in the follicular phase had baseline differences in the most abundant miRNAs and exercise-relevant miRNAs

SUBMITTER: Kargl CK 

PROVIDER: S-EPMC12937090 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature