Incidence of treated brain metastases among patients with stage I-III breast cancer: A population-based study.

ABSTRACT:

Background

The incidence and risk factors for brain metastases among patients with stage I-III breast cancer remain poorly defined.

Patients and methods

We conducted a population-based cohort study using Ontario health administrative databases to identify patients diagnosed with stage I-III breast cancer between 2009 and 2021. Treatment of brain metastases with surgery or radiation was extracted from the same databases. Patients were stratified by breast cancer subtype: human epidermal growth factor receptor 2 positive/hormone receptor positive (HER2+/HR+), HER2+/hormone receptor negative (HER2+/HR-), HR+/HER2-, and triple-negative breast cancer (TNBC). Primary outcomes were the cumulative incidence of treated brain metastases and time to brain metastasis (TTBM) as defined b

SUBMITTER: Jerzak KJ 

PROVIDER: S-EPMC12937143 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature