Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies.

ABSTRACT:

Introduction

Viroporins are small multifunctional proteins that modify cellular membranes facilitating processes such as viral nucleic acid entry and the release of virions from infected cells. We are interested in studying the evolutionary relationships among these proteins, in particular their organization into families and superfamilies.

Methods

We applied a variety of computational strategies to perform comparative genomics analyses of 120 viral genomes, using the phylogenetic profile method. This allowed the identification of 12 families, organized into four functionally related groups. Additionally, we compiled a list of 40 families from the Transporter Classification Database (TCDB) with viroporin-like attributes (i.e., length ≤300 aas, similar topologies, and/or docu

SUBMITTER: Wang J 

PROVIDER: S-EPMC12937198 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature