Calorie Restriction Effects on Aging, Learning Performance, and Transcription in Aged Aplysia californica.

ABSTRACT: Along with increasing an animal's lifespan, calorie restriction (CR) is shown to improve an animal's cognition. To elucidate the molecular differences that accompany CR that may benefit cognition, sibling Aplysia californica were reared on either an ad-lib (AL) or CR diet. Siblings from each diet were trained in two behaviors, learning food is inedible (LFI) and habituation of the tail withdrawal reflex (TWR), at two time points along their lifespans: younger animals at training time 1 (TT1) and aged siblings at training time 2 (TT2). In analysis by diet, TT2 CR animals' learning performance was on par with their TT1 CR siblings in both paradigms, illustrating a maintenance of cognition in age. Meanwhile, TT2 AL animals performed worse than TT1 AL siblings in habituation but better in LFI,

SUBMITTER: Randolph EC 

PROVIDER: S-EPMC12937505 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature