Patient-Specific Lattice Implants for Segmental Femoral and Tibial Reconstruction (Part 2): CT-Based Personalization, Design Workflows and Validation-A Review.

ABSTRACT: Patient-specific lattice implants (PSLIs) and modular porous scaffolds have emerged as promising solutions for treating diaphyseal segmental defects of the femur and tibia, particularly where conventional reconstruction methods fall short. This second part of our two-part review focuses on how current studies transform computed tomography (CT) and μCT datasets into architected lattice implants, as well as how these constructs are fabricated and numerically, mechanically, biologically, and clinically verified. We outline imaging pipelines, including Digital Imaging and Communications in Medicine (DICOM) acquisition, segmentation, contralateral mirroring, and Hounsfield Units (HU)-density-elasticity mapping, and show how these choices impact finite element (FE) models and print-ready geometr

SUBMITTER: Rezapourian M 

PROVIDER: S-EPMC12938023 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature