Integrated Transcriptomic and Proteomic Analyses Uncover the Mechanisms of Keratin Degradation in <i>Lysobacter brunescens</i> YQ20.

ABSTRACT: Several strains of Lysobacter have demonstrated keratin-degrading capabilities, positioning them as promising candidates for the degradation and utilization of wool waste. In our previous study, a novel strain, Lysobacter brunescens YQ20, exhibiting highly efficient keratin degradation capabilities, was isolated. In this study, transcriptomic and proteomic analyses were conducted to elucidate the underlying mechanisms of keratin degradation. Our findings revealed that several metabolic pathways, specifically, valine, leucine, and isoleucine biosynthesis; phenylalanine, tyrosine, and tryptophan biosynthesis; glycine, serine, and threonine metabolism; and histidine metabolism, were highly active during keratin degradation, thereby supporting the growth and metabolism of L. b

SUBMITTER: Wei MY 

PROVIDER: S-EPMC12938321 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature