Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice.

ABSTRACT: The increase in maternal age of pregnancies is a global phenomenon that may have wide-ranging implications for the future health of the next generations. We have previously shown that oocytes from females at advanced maternal age (AMA F0) accumulate intracytoplasmic lipid droplets (LDs), and that oxidative changes to lipids in oocytes from AMA F0 mice are maintained in preimplantation embryos. Here we explore whether oxidative changes are transmitted to the foetus, and what effects this has on neonatal and adult organ development, and the transgenerational inheritance of these changes. First, we show increased antioxidants in lipid-rich organs (liver and brain) of AMA-derived prenatal mice (AMA F1), indirectly showing increased oxidative stress. Then, we provide evidence of metabolic repro

SUBMITTER: Gulzar H 

PROVIDER: S-EPMC12938507 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature