Genome-Wide Association Study of Genetic Variants Associated with Serum Albumin Levels in Chinese Winter Sports Athletes.

ABSTRACT: This study aimed to explore genetic variants associated with serum albumin (ALB) levels in Chinese winter sports athletes using genome-wide association analysis (GWAS) and to investigate potential regulatory mechanisms using bioinformatics annotation. A total of 382 Chinese winter sports athletes were recruited. ALB levels were compared between elite and non-elite athletes. GWAS was conducted using PLINK v1.9, with ALB as the phenotype and sex, age, and principal components as covariates. Associated SNPs were annotated using GTEx and SNPnexus. No significant differences were observed in ALB levels between elite and non-elite male or female athletes, and ALB levels in all groups followed a normal distribution. We identified 113 SNPs reaching a suggestive significance threshold (p < 1

SUBMITTER: Mei T 

PROVIDER: S-EPMC12938714 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature