Repeatability of diffusion-weighted arterial spin labeling MRI for mapping blood-brain barrier water exchange rate at different postlabel delays.

ABSTRACT:

Purpose

This study sought to determine the intrasession repeatability of the diffusion-weighted (DW) arterial spin labeling (ASL) sequence at different postlabel delays (PLDs).

Methods

We first performed numerical simulations to study the accuracy of the two-compartment water exchange rate (Kw) fitting model with added Gaussian noise for DW PLDs at 1500, 1800, and 2100 ms. Ten young, healthy participants then underwent a structural T₁ scan and two intrasession in vivo DW ASL scans at each PLD on a 3T MRI. The Kw, arterial transit time (ATT), and cerebral blood flow maps were linearly registered to the structural images, which were then segmented using FreeSurfer into masks with 35 bilateral gray-matter regions.

Results

Simulation results showed that the Kw

SUBMITTER: Zhu YD 

PROVIDER: S-EPMC12938883 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature