CD36 rs1761667 Polymorphism and Its Impact on Molecular Signatures in Bladder Cancer.

ABSTRACT:

Background

Bladder cancer remains a heterogeneous disease, and genetic factors are increasingly recognized as potential contributors to its pathogenesis. CD36, a multifunctional scavenger receptor implicated in lipid metabolism and tumor progression, has not been previously investigated in relation to bladder cancer-associated polymorphisms.

Objectives

This study examined the relationship between the rs1761667 variant and CD36 mRNA expression.

Methods

Our study included 30 patients with bladder cancer and 19 controls. PCR-RFLP genotyping for rs1761667 and RT-qPCR quantification of CD36 mRNA expression, with GAPDH as the reference gene, were performed. Expression levels were analyzed using the 2^-ΔΔCt method, and statistical significance was defined as p</

SUBMITTER: Pavalean MI 

PROVIDER: S-EPMC12938890 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature