Venezuelan Equine Encephalitis Virus Antagonizes the cGAS-STING Pathway.

ABSTRACT: Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne pathogen causing low mortality but high morbidity in humans, with 4-14% cases exhibiting neurological complications. While the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is canonically associated with double-stranded DNA (dsDNA) detection, it has been shown to respond to RNA viruses and subsequently limit viral pathogenesis. Several viruses antagonize this signaling cascade, underscoring the importance that cGAS-STING plays in host immunity. Previous studies regarding single-stranded RNA viruses revealed that cGAS-STING limits viral replication in Old World alphavirus chikungunya virus infections, but little is known about New World alphaviruses such as VEEV. Here, we investigate the impact tha

SUBMITTER: Heath BN 

PROVIDER: S-EPMC12939000 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature