Heat-Treated <i>Lacticaseibacillus rhamnosus</i> Strains Modulate Inflammatory and Metabolic Processes in <i>In Vitro</i> Systems Relevant to Canine Osteoarthritis.

ABSTRACT: Canine osteoarthritis is a progressive degenerative joint condition characterized by inflammation, structural damage, pain, and impaired joint function. Osteoarthritis risk is influenced not only by well-established factors such as age, genetics, obesity and underlying arthropathies, but also by systemic conditions such as low-grade inflammation and sarcopenia. Current interventions are primarily focused on pain relief rather than mitigating physiological impairment, despite recent veterinary guidelines. In this study, several preclinical models were employed to identify postbiotic candidates with potential to promote canine joint health. An initial screening of nine heat-treated bacterial strains identified two Lacticaseibacillus rhamnosus strains, PRIOME^® JH and HT-PB01

SUBMITTER: Rago L 

PROVIDER: S-EPMC12939062 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature