Computational Modelling and Clinical Validation of an Alzheimer's-Related Network in Brain Cancer: The SKM034 Model.

ABSTRACT: Cancer and Alzheimer's disease (AD) display an inverse relationship, and there is a need to further explore this interplay. One key genetic contributor to AD is SORL1, the loss of which is thought to be causally related to AD development. SORL1 also appears to be implicated in cancer. To examine SORL1 and its network, this article simulated SORL1 and its interactions via signal-flow Boolean modelling, including in silico knockouts (mirroring in vivo loss-of-function mutations). This model (SKM034) predicted a total of 29 key changes in molecular relationships following the loss of SORL1 or another highly connected protein (ERBB2). Literature validation demonstrated that 2 of these predictions were at least partially validated experimentally, whilst 27 were Potentially Novel Predicti

SUBMITTER: Montalbo K 

PROVIDER: S-EPMC12939318 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature