Identification of Paraptosis-Related Renal Cell Carcinoma Subtypes, Construction of a Prognostic Signature, and Determination of Tumor Microenvironment Landscape Using Bioinformatic Analysis and Experimental Verification.

ABSTRACT: Renal cell carcinoma (RCC) is a common and deadly urological cancer, for which there are no robust prognostic biomarkers or personalized treatment strategies. Paraptosis, a distinct form of regulated cell death marked by cytoplasmic vacuolization, is being increasingly recognized for its roles in tumorigenesis and therapy responses, yet its functional implications in RCC remain poorly defined. Transcriptomic profiles and corresponding clinical metadata from the TCGA-KIRC and GSE33371 datasets were systematically analyzed to characterize the paraptosis-related gene (PaRG) expression profile in renal cell carcinoma (RCC). Patients were categorized into two subtypes via consensus clustering, 574 overlapping differentially expressed genes (DEGs) were identified, and a four-gene (COL7A1, RNASE2

SUBMITTER: Qin M 

PROVIDER: S-EPMC12939344 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature