Voluntary wheel-running reduces harmful drinking in a genetic risk model for drinking to intoxication.

ABSTRACT: Physical activity (PA) may provide an effective and equitable treatment option for addressing the harm associated with Alcohol Use Disorders (AUDs). Wheel-running (WR) - a well characterized rodent model of PA - reduces intake and craving for many drugs of abuse; however, its effects on models of harmful ethanol intake are mixed. This may in part be due to critical differences in drinking paradigm, genetics background, chronicity of ethanol, and the modality and duration of PA being tested. To compliment and extend prior work, we evaluated whether key stages of PA development would differentially reduce binge-like ethanol drinking in inbred High Drinking in the Dark (iHDID-1) mice, a unique genetic risk model for drinking to intoxication. AUD is a chronic, relapsing disorder. To better ref

SUBMITTER: Grigsby K 

PROVIDER: S-EPMC12939583 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature