Wnt5a Regulates Embryonic Mullerian Duct Development Through the Non-Canonical Wnt PCP Pathway.

ABSTRACT: Müllerian anomalies are anatomical variations of the female reproductive tract resulting from the incomplete development of the embryonic Müllerian ducts. The molecular mechanisms driving Müllerian duct development are complex and poorly understood, resulting in the largely unexplained aetiology of these conditions. WNT5A is a critical regulator of key developmental processes, including patterning, cell proliferation, and migration. Mutations of WNT5A have been associated with Robinow syndrome, a congenital condition characterized by skeletal and genital anomalies. In the mouse, WNT5A is necessary for the posterior development of the Müllerian duct, and ablation of Wnt5a results in vaginal agenesis. However, Wnt5a-/- uterine horns are hypoplastic and over 60% shorter t

SUBMITTER: Kyei-Barffour I 

PROVIDER: S-EPMC12939794 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature