A One Health approach to bovine coronavirus vaccine development, using LSDV as a live virus vector.

ABSTRACT: Bovine coronavirus (BCoV) causes significant pneumo-enteric infections in cattle and other ruminants. A BCoV-like coronavirus was previously found in a symptomatic human child and shares 97.1% sequence identity with one of the more prevalent human coronaviruses, HCoV-OC43. Zoonosis of a virulent BCoV from livestock is a feasible threat. Lumpy skin disease virus (LSDV) is a poxvirus that can be used as a live attenuated dual vaccine vector in cattle and potentially as a replication-deficient vaccine vector, in humans. This paper explores the development of a vaccine, considering the increasingly significant One Health approach, which recognizes the importance of curbing disease at the animal-human interface to prevent future epizootics and pandemics. A recombinant LSDV (LSDV-BCoV-K1L) was d

SUBMITTER: Chineka N 

PROVIDER: S-EPMC12940145 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature