Perfusion-Limited Efficacy of Platelet-Rich Plasma in Adipose Tissue Grafts.

ABSTRACT: Autologous adipose tissue (AT) grafting is often compromised by insufficient early vascularization, leading to ischemia, fibrosis, and inconsistent long-term volume retention. Incorporating platelet-rich plasma (PRP) into AT bioinks offers a clinically accessible means to enhance vascular recruitment, but the in vivo impact of PRP dosage remains unclear. Here, we investigated how PRP concentration, uniformly integrated into a previously reported clinically relevant AT bioink, regulates vascular infiltration, tissue remodeling, and overall graft survival. High-dose PRP markedly improved graft performance, including an 8-fold increase in highly perfused regions, a 3.8-fold enhancement in adipocyte survival, a 1.67-fold reduction in fibrosis, and a 2.51-fold increase in collagen III depositio

SUBMITTER: Jamal Mohamed H 

PROVIDER: S-EPMC12940529 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature