<i>Pseudomonas plecoglossicida</i> hijacks host glycolysis to induce hypoglycemic shock in large yellow croakers ( <i>Larimichthys crocea</i>).

ABSTRACT: Bacterial sepsis frequently progresses to hypoglycemia, a metabolic condition strongly associated with increased mortality. In this study, large yellow croakers were injected with phosphate-buffered saline (PBS) to establish a control group (CG) or exposed to an equivalent dose of Pseudomonas plecoglossicida, after which infected fish were categorized into moribund group (MG) or survival group (SG). Results showed that hepatic glycogen was rapidly depleted across all infected croakers, but severe hypoglycemia emerged only in the MG group, with blood glucose reduced to 0.80 mmol/L. Infection produced substantial oxidative and redox disruption, including accumulation of lipid peroxides, depletion of reduced glutathione (GSH), and a decline in the NAD ⁺/NADH ratio, al

SUBMITTER: Sun YJ 

PROVIDER: S-EPMC12940688 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature