Rescuing fertility: C-Phycocyanin prevents ovarian damage through NRF2-mediated ferroptosis pathways in polycystic ovary syndrome models.

ABSTRACT: Polycystic ovary syndrome (PCOS), a common female endocrine disorder marked by disrupted folliculogenesis and hyperandrogenism, is increasingly linked to oxidative stress. Despite this association, the mechanistic basis remains poorly characterized. C-Phycocyanin (C-PC), a cyanobacteria-derived protein with potent antioxidant properties, has demonstrated therapeutic potential for treating PCOS, though the molecular pathways mediating its effects have yet to be delineated. This study employed both a dehydroepiandrosterone (DHEA)-induced murine model and DHEA-challenged human granulosa cells (KGN) to elucidate the regulatory role of C-PC. In vivo, oral administration of C-PC restored estrous cyclicity, reduced the prevalence of cystic follicles, and normalized circulating levels of te

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12940770 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature