Anti-Inflammatory Effects of Marine-Derived Resorcylic Acid Lactone Derivatives in Ulcerative Colitis via the MAPK/ERK Pathway.

ABSTRACT: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent inflammation of the colonic mucosa, and there is currently a lack of safe and effective treatment drugs. Resorcylic acid lactones (RALs) are a natural product that have been reported to have anti-inflammatory effects. However, the mechanism of whether RALs can treat UC and their anti-inflammatory effects remains underexplored. In this study, three new RAL derivatives, Penicillactones A-C (1-3), along with seven known analogs (4-10), were isolated from the marine fungus Penicillium sp. HN20. The structures of compounds 1-3 were elucidated by spectroscopic methods, ¹³C NMR theoretical calculations, and ECD analysis. Among these, compound 4 exh

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12941434 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature