Deep Biological Clocks in Critical Care Medicine: A Scoping Review Toward Translational Precision Care.

ABSTRACT: Background: Outcomes after critical illness vary markedly despite similar diagnoses and severity scores, underscoring the limitations of chronological age and conventional Intensive Care Unit (ICU) prognostic tools. Personalization of critical care is increasingly essential to improve not only short-term survival but also long-term post-discharge outcomes. Biological aging clocks provide a quantitative framework to capture physiological reserve, immune competence, and vulnerability to stress. Methods: We conducted a scoping review of original human studies published between January 2015 and October 2025 that evaluated biological aging biomarkers in adult ICU populations. PubMed/MEDLINE, Scopus, Web of Science, and Embase were searched, with backward citation screening. Res

SUBMITTER: Cheyne I 

PROVIDER: S-EPMC12941452 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature