Chromatin Remodeling Factor Arp8 Is Involved in the Regulation of Aflatoxin Biosynthesis and Fungal Pathogenicity of <i>Aspergillus flavus</i>.

ABSTRACT: Aspergillus flavus Link, 1809 is a pathogenic fungus widely present in the environment. It can infect plants and also acts as an opportunistic pathogen affecting humans and other animals. The aflatoxins (AFs), it produces, can cause cancers such as liver cancer. Therefore, in-depth research into the pathogenic mechanisms of A. flavus is crucial. Arp8 (Actin-like protein Arp8) is a unique subunit within the chromatin remodeling complex INO80, regulating processes including chromatin remodeling. However, the biological function of Arp8 in A. flavus remains unclear. This study constructed A. flavus arp8 knockout (Δarp8) and complementation (Com-arp8) strains via homologous recombination. Subsequent research revealed that following the deletion of a

SUBMITTER: Ma D 

PROVIDER: S-EPMC12941487 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature