Unusual Sporotrichosis: A New Concept Proposal on the Unexpected Faces of <i>Sporothrix</i> spp. Infection.

ABSTRACT: "Unusual sporotrichosis", a concept proposed in this review, refers to severe, extracutaneous, or anatomically atypical manifestations of sporotrichosis occurring in immunocompetent hosts and represents an underrecognized clinical subset associated with important diagnostic and therapeutic challenges. This systematic review aimed to characterize unusual sporotrichosis worldwide and to clarify its epidemiological, clinical, diagnostic, and therapeutic patterns. Following a registered protocol and PRISMA guidelines, PubMed, Scopus, and BVS/LILACS were searched up to November 2025 using a PICO-based strategy. Eligible studies included peer-reviewed case reports and case series with laboratory-confirmed sporotrichosis in patients without immunosuppression, diabetes mellitus, alcoholism, or oth

SUBMITTER: da Silva JA 

PROVIDER: S-EPMC12941687 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature