Histidinol-Phosphate Phosphatase FoHis2 Is Essential for Growth, Stress Responses, and Full Virulence in <i>Fusarium oxysporum</i> f. sp. <i>cubense</i>.

ABSTRACT: Fusarium wilt of banana, caused by Fusarium oxysporum f. sp. cubense (Foc), is a destructive vascular disease that seriously threatens global banana production. To investigate the contribution of histidine metabolism to Foc growth and pathogenicity, we functionally characterized FoHis2, a putative histidinol-phosphate phosphatase in Foc race 4 (Foc4). Targeted deletion of FoHis2 severely compromised histidine prototrophy, with the ΔFoHis2 mutant growing slowly on potato dextrose agar and even more slowly on minimal medium (MM, no histidine added). Exogenous histidine fully restored the mutant growth to wild-type (WT) levels, whereas histidinol supplementation rescued the colony size but not the reduced aerial mycelium formation. The ΔFoHis2 mutant exhibit

SUBMITTER: Liu L 

PROVIDER: S-EPMC12941702 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature