Marine Microalga <i>Tisochrysis lutea</i> F&M-M36 Modulates Gut Microbiota and Intestinal Cholesterol Transport Gene Expression in Association with Selected Early-Stage Metabolic Alterations Under High-Fat Feeding.

ABSTRACT: Modulation of the gut microbiota represents a promising approach to counteract diet-induced metabolic alterations, with microalgae emerging as potential interventions. Building on our previous in vivo evidence that dietary supplementation with the marine microalga Tisochrysis lutea F&M-M36 (T. lutea) positively modulates selected metabolic alterations under high-fat feeding, the present study aimed to identify potential associations between these metabolic changes and coordinated modifications of the gut microbiota. Animals were fed normal-fat (NF), high-fat (HF), or HF supplemented with 5% T. lutea (HFTiso) diets for three months. Gut microbial profiles were analyzed by 16S rRNA sequencing and correlated with plasma lipids, glucose, blood pressure, fecal lipid excreti

SUBMITTER: Bigagli E 

PROVIDER: S-EPMC12941734 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature