Aging-Induced QT Prolongation as a Potential Contributor to Longevity.

ABSTRACT: The objective of this paper was to review the possibility that the QT interval may be a marker of adult human longevity or life expectancy. Following a literature review, data supporting this possibility was assembled and consists of the following. First, in adults, QT interval increases with increasing age. This is analogous to aging-induced hypertension and diabetes mellitus, both of which are associated with shorter longevity. Second, older persons frequently die suddenly regardless of whether or not they have chronic illnesses for which death is expected. Third, longer QTintervals are associated with increased probability of sudden death. Fourth, patients with two conditions associated with accelerated brain aging, namely dementia and Parkinson's disease, show longer QTcs than age-matc

SUBMITTER: Rabkin SW 

PROVIDER: S-EPMC12942042 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature