Effects of Leucine Supplementation on Athletic Performance, Central Fatigue, and Serum Metabolism in Endurance Athletes: A Randomized Controlled Trial and Targeted Metabolomics Study.

ABSTRACT: Objectives: We aimed to investigate the effects of 6 weeks of leucine supplementation on athletic performance, central fatigue, and serum metabolome in endurance athletes, and to provide valuable insights into nutritional strategies for endurance athletes. Methods: Twenty cross-country skiers were recruited and randomized into 2 groups: the placebo (PLA) group and the leucine (LEU) group. Subjects were given leucine (8.5 g) + sucrose (14 g) or only sucrose (14 g) supplements twice each day from Monday to Saturday for 6 weeks. Test parameters include body composition, aerobic capacity, isokinetic muscle strength, blood biochemistry, and targeted metabolomics. Results: After intervention, compared to the PLA group (1) the ankle muscle strength (p = 0.01), VO₂

SUBMITTER: Li T 

PROVIDER: S-EPMC12942045 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature