Endometrial microbiota-targeted therapies for chronic endometritis-associated recurrent implantation failure and their impact on IVF outcomes: A systematic review and methodological quality assessment.

ABSTRACT:

Introduction

Recurrent implantation failure (RIF) is a multifactorial reproductive disorder, often associated with chronic endometritis (CE) and alterations of the intrauterine microbiota.

Material and methods

This systematic review evaluated whether microbiota-targeted therapeutic interventions improve pregnancy outcomes in women with CE-associated RIF undergoing in vitro fertilization (IVF)-embryo transfer (ET). Study quality and risk of bias were assessed using the Newcastle-Ottawa Scale (NOS) and the Revised Cochrane Risk of Bias in Non-Randomized Studies - of Interventions (ROBINS-I).

Results

Four studies met the inclusion criteria, encompassing antibiotic, probiotic, and nutraceutical interventions. Considerable heterogeneity was observed in study design, diagno

SUBMITTER: Doroftei B 

PROVIDER: S-EPMC12942084 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature