Novel Metabolites of <i>Xylaria thienhirunae</i> SWUF17-44.1 with Biological Activities and Molecular Docking Analysis.

ABSTRACT: The extract of Xylaria thienhirunae SWUF17-44.1 displayed broad-spectrum antimicrobial activity, with higher potency against Gram-positive bacteria than Gram-negative strains. Minimum inhibitory concentration (MIC) values were as low as 0.63 µg/µL for Staphylococcus aureus and 1.25 µg/µL for Bacillus subtilis, whereas higher values were observed for Escherichia coli and Pseudomonas aeruginosa. The extract also inhibited fungal growth, with MICs of 6.25 μg/μL against Candida albicans and C. tropicalis. Strong antioxidant activity was observed (DPPH IC₅₀ = 0.706 ± 0.022 μg/μL; ABTS IC₅₀ = 0.251 ± 0.019 μg/μL), correlated with high phenolic content. Moderate anti-inflammatory activity was confirmed via nitric oxide inhibit

SUBMITTER: Thongsuwan P 

PROVIDER: S-EPMC12942104 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature