Corallomycetellains A-J, Cytotoxic Epipolythiodioxopiperazine Alkaloids Isolated from the Fungi <i>Corallomycetella repens</i> HDN23-0007.

ABSTRACT: Ten new epipolythiodioxopiperazine (ETP) alkaloids, named corallomycetellains A-J (1-10), along with one known analogue, haematocin (11), were isolated from the fungi Corallomycetella repens HDN23-0007. Their structures, including absolute configurations, were established by comprehensive spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1-2 represent the first two examples of aranotin-type ETPs possessing an aromatic indole moiety. Compounds 2-4 all featured a unique C2-methyl disulfide substituent, whereas compound 4 additionally possessed a C2'-oxomethyl group. In in vitro cytotoxicity assays, compounds 7-10, which contained α-α' polysulfide bridges,

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12942383 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature