Seed-competent tau oligomers' activity correlates with the rate of progression in sporadic Alzheimer's disease patients.

ABSTRACT: BackgroundWhile it is clear that abnormal tau structures contribute to the clinical symptoms of Alzheimer's disease (AD), which of the many structural entities found in the AD brain underlie templated misfolding and progression of disease remains uncertain. However, their identification is crucial to target for more effective diagnostics and therapeutics.ObjectiveTo identify the most pathogenic tau species driving Alzheimer's disease progression.MethodsWe compared the biochemical and templated seeding properties of tau isolated from post-mortem brain tissue of patients with varying rates of clinical progression, categorized as rapid, slow, or typical, based on longitudinal decline in cognitive performance assessed by Clinical Dementia Rating Sum of Boxes scores. Sarkosyl-insoluble filament

SUBMITTER: Perbet R 

PROVIDER: S-EPMC12942507 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature