Bilateral Optic Neuritis Following Acute Glyphosate Inhalation: A Case Report.

ABSTRACT:

Background

Bilateral optic neuritis is a rare condition generally associated with inflammatory, demyelinating, or toxic causes. Its association with glyphosate exposure has rarely been documented.

Case presentation

A 66-year-old man with hypertension, hypercholesterolemia, and hypothyroidism developed rapid bilateral vision loss within hours after acute inhalational exposure to glyphosate during agricultural work. MRI showed bilateral optic nerve hyperintensity consistent with optic neuritis. Cerebrospinal fluid and serum anti-NMO antibody tests were negative, while visual evoked potentials demonstrated increased latencies. High-dose corticosteroid therapy led to progressive clinical improvement. At follow-up, MRI revealed no new lesions and the patient experienced near-comp

SUBMITTER: Grasso R 

PROVIDER: S-EPMC12942672 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature